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Mushrooms Strengthen Immunity According to Mouse Research Study
By Anne Harding
March 6, 2009, NEW YORK - Mushrooms could give the immune system a hand
in attacking foreign invaders, if the effects in mice translate to
What's more, the common white button mushroom had stronger
immune-boosting effects than more exotic -- and more expensive -- fungi
such as oyster and shiitake mushrooms, Dr. Keith Martin of Arizona State
University in Mesa and his colleagues found.
"What really stood out is that the white button mushrooms seemed to be
the most effective," Martin told Reuters Health. "That's good, because
those probably are the most affordable in the supermarket."
One probably wouldn't suspect, he added, that these humble fungi are
actually "powerhouses for boosting the immune system."
Mushrooms have long been used in traditional medicine, and mushroom
extracts are popular as dietary supplements today, Martin and his team
point out in their report in the online journal BMC Immunology. Studies
of individual components of mushrooms in lab dishes and animals suggest
they may help increase the immune system's ability to fight tumors.
To investigate whether whole mushrooms might offer a similar benefit,
the researchers performed a series of experiments using crimini, maitake,
oyster, shiitake, and white button mushrooms added to the diets of mice.
The team found that the effects on healthy animals were much weaker than
the effects seen in isolated immune cells in lab studies. Rodents that
ate a diet consisting of 2% white button mushrooms for four weeks showed
no changes in their immune system, and no signs of toxicity.
However, when the researchers fed the animals a chemical that triggers
colon inflammation and can promote the growth of colon tumors, the
rodents that had mushrooms in their diet were protected from weight loss
and colon injury.
"We should expect beneficial effects in humans, with the key being that
the mushrooms alone are not setting off the immune system," Martin
To get the equivalent amount of mushrooms consumed by the mice in the
study, Martin added, a person would need to eat about 100 grams or 3.5
ounces -- roughly 2.5 cups of raw mushrooms -- daily.
SOURCE: BMC Immunology, online February 20, 2009.
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